{"id":449,"date":"2019-07-11T06:24:05","date_gmt":"2019-07-11T14:24:05","guid":{"rendered":"https:\/\/seiple.scripps.edu\/?p=449"},"modified":"2019-07-11T06:24:05","modified_gmt":"2019-07-11T14:24:05","slug":"the-big-streptogramin-story-complete-with-250-pg-si","status":"publish","type":"post","link":"https:\/\/seiple.scripps.edu\/index.php\/2019\/07\/11\/the-big-streptogramin-story-complete-with-250-pg-si\/","title":{"rendered":"The big streptogramin story, complete with 250-pg SI."},"content":{"rendered":"

With an incredible, multidisciplinary team from UCSF and Schrodinger, we have been able to overcome streptogramin resistance caused by virginiamycin acetyltransferase! We have posted the results on ChemRXiv (bit.ly\/2xlFS2q), making this our first pre-print (by only a few hours! see next post…)<\/p>\n

We are very proud of this story. It features >60 structurally complex analogs, >8 cryo-EM structures, and hundreds of MICs. And a 250+-page Supporting Information. Congrats to Qi, Jenna, and the whole team!!<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

With an incredible, multidisciplinary team from UCSF and Schrodinger, we have been able to overcome streptogramin resistance caused by virginiamycin acetyltransferase! We have posted the results on ChemRXiv (bit.ly\/2xlFS2q), making this our first pre-print (by only a few hours! see next post…) We are very proud of this story. It features >60 structurally complex analogs, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-449","post","type-post","status-publish","format-image","hentry","category-uncategorized","post_format-post-format-image"],"_links":{"self":[{"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/posts\/449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/comments?post=449"}],"version-history":[{"count":1,"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/posts\/449\/revisions"}],"predecessor-version":[{"id":451,"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/posts\/449\/revisions\/451"}],"wp:attachment":[{"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/media?parent=449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/categories?post=449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/seiple.scripps.edu\/index.php\/wp-json\/wp\/v2\/tags?post=449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}